Antidepressant Medication Unwanted Effects Such as Weight, Blood Pressure Changes Vary Depending on Medication

• A extensive latest study discovered that the adverse reactions of depression drugs differ considerably by drug.
• Some pharmaceuticals led to decreased mass, whereas other medications resulted in weight gain.
• Pulse rate and BP also differed notably across medications.
• Individuals experiencing persistent, intense, or troubling unwanted effects should speak with a medical provider.

Recent studies has discovered that depression drug adverse reactions may be more varied than earlier believed.

This comprehensive study, released on October 21, assessed the impact of depression treatments on more than 58,000 individuals within the beginning 60 days of starting treatment.

These investigators studied 151 investigations of 30 medications frequently employed to address major depression. Although not everyone experiences adverse reactions, certain of the most frequent recorded in the research were changes in body weight, BP, and metabolic indicators.

The study revealed significant disparities among antidepressant drugs. As an illustration, an 60-day treatment period of one medication was associated with an average weight loss of around 2.4 kilos (approximately 5.3 lbs), while another drug patients gained close to 2 kg in the equivalent timeframe.

Additionally, marked fluctuations in cardiac function: one antidepressant tended to decrease cardiac rhythm, in contrast nortriptyline increased it, causing a disparity of approximately 21 BPM across the two drugs. Arterial pressure differed as well, with an 11 millimeters of mercury difference observed among one drug and another medication.

Clinical experts noted that the study's results aren't new or surprising to psychiatrists.

"We've long known that distinct depression drugs differ in their impacts on body weight, blood pressure, and additional metabolic indicators," one specialist stated.

"However, what is notable about this study is the rigorous, relative quantification of these differences across a broad array of physiological parameters utilizing findings from more than 58,000 individuals," this specialist added.

This investigation offers comprehensive proof of the degree of unwanted effects, some of which are more prevalent than different reactions. Typical depression drug unwanted effects may include:

• stomach problems (sickness, diarrhea, irregularity)
• sexual problems (decreased libido, anorgasmia)
• weight changes (addition or decrease, according to the agent)
• sleep problems (inability to sleep or drowsiness)
• mouth dryness, moisture, migraine

Meanwhile, rarer but medically important side effects may encompass:

• elevations in arterial pressure or heart rate (notably with SNRIs and some tricyclic antidepressants)
• low sodium (particularly in senior patients, with SSRIs and serotonin-norepinephrine reuptake inhibitors)
• increased liver enzymes
• Corrected QT interval lengthening (chance of irregular heartbeat, especially with one medication and certain tricyclic antidepressants)
• diminished feelings or lack of interest

"A key factor to remember here is that there are various varying classes of antidepressants, which result in the distinct unwanted drug effects," another expert commented.

"Additionally, depression treatments can influence each patient differently, and negative effects can vary depending on the specific drug, dosage, and individual elements including metabolic rate or co-occurring conditions."

Although certain side effects, like changes in rest, appetite, or vitality, are quite common and frequently enhance with time, other effects may be less frequent or continuing.

Antidepressant adverse reactions may differ in severity, which could require a adjustment in your drug.

"A adjustment in depression drug may be necessary if the patient encounters continuing or intolerable unwanted effects that don't get better with duration or supportive measures," a professional commented.

"Furthermore, if there is an appearance of recent health problems that may be exacerbated by the current drug, for example hypertension, abnormal heart rhythm, or considerable mass addition."

Individuals may also contemplate speaking with your physician concerning any lack of significant progress in depression-related or anxiety indicators after an appropriate evaluation duration. The adequate testing period is typically 4–8 weeks at a therapeutic dose.

Personal inclination is also significant. Some patients may want to avoid specific unwanted effects, like sexual problems or {weight gain|increased body weight|mass addition